With two outs in the top of the sixth inning, Astros right-hander Brandon Backe threw an 0-2 pitch that hit Guillen on his left forearm. Guillen knelt down for a few minutes while manager Frank Robinson and assistant athletic trainer Michael McGowan attended the right fielder. Guillen was seen shaking his wrist, but a few minutes later, he left the game on his own power. Marlon Byrd pinch-ran for Guillen and remained in the game in right field.
Guillen took X-rays, and it was revealed that he has a forearm contusion. Robinson said that Guillen will not play Saturday evening against Houston.
After the game, Guillen's mood was the antithesis of what it was on Thursday. That day he was upset that Mets starter Pedro Martinez hit him twice with pitches, but on Friday, Guillen understood that Backe was trying to throw inside.
"[The forearm] is pretty sore. I was lucky that it didn't get my wrist. I'll be fine," Guillen said. "I don't want people to worry about me. I'll be fine. I know what to do to be in there. That's part of the game. Everybody knows [Backe] was trying to come inside. You have to get use to it."
Friday marked the fourth time Guillen was hit by a pitch this season. The previous three came against the Mets. In fact, dating back to 2003, Guillen has been hit by pitches 52 times.
Asked if there was anyway to avoid getting hit by pitches, Guillen said, "I'm on top of the plate, and people try to pitch me inside. I don't know. What can I tell you. Next time you see me, I'm going to start wearing those shin guards like Barry Bonds -- wrist and shoulder. That's it. You have to protect that arm, man. It's a long season. I know everybody is going to try to come in there."
Bill Ladson is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.