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The 24-year-old shortstop upped his RBI total from 13 to 20 in the game.
Difo came to the plate with eight runners on base Tuesday night and drove in six. The other RBI was Difo himself on the homer.
In the first, Difo drove in the first run of the game with a double to right. He broke the game open with a grand slam, the second of his career, in the fourth and finished the evening with a two-run single in the eighth.
Difo's first four-hit game of the season raised his average from .224 to .234.
William Boor is a reporter for MLB.com. Follow him on Twitter at @wboor. This story was not subject to the approval of Major League Baseball or its clubs.