There is no definitive timetable as to when both players will return. Guzman will have an MRI on the thumb and Colome will most likely have surgery.
Guzman hurt his thumb in the top of the fifth inning. Indians second baseman Josh Barfield attempted to steal second base, but he was tagged out by Guzman for the last out the inning. On the tag, Guzman's thumb hit Barfield's helmet hard. However, Guzman never left the game and had two more at-bats. In fact, in his last at-bat, in the bottom of the eighth inning, Guzman lined out hard to Barfield for the first out of the inning.
After the game, Guzman had a big cast on the thumb and acknowledged that he was upset that he had to go on the DL for the second time this season. He previously missed a month because of a left hamstring strain. For now, the Nationals believe Guzman will be out two to four weeks because of this latest injury.
Guzman is having one of the best seasons of his career. He is hitting .329 with two home runs and 14 RBIs.
"I feel bad right now," Guzman said. "I feel sad because I want to play. I want to help my team. I can't do anything now. [Monday], I'll let you know more. I think I will come back this year."
Colome's problems with his buttocks is nothing new. He had the same problem during Spring Training and had to miss a few exhibition games, but was eventually able to work around the issue. This time, according to a baseball source, there are complications, and Colome needs surgery to fix the problem.
In his finest big-league campaign to date, Colome is 4-0 with one save and a 2.76 ERA in 40 games with the Nationals.
"I don't feel good. I can't talk," Colome said. "I have to wait until tomorrow. I'm going straight to the doctor."
General manager Jim Bowden and manager Manny Acta were not available for comment.
With Guzman and Colome on the disabled list, the Nationals are expected to select the contract of infielder D'Angelo Jimenez from Triple-A Columbus and recall reliever Chris Schroder, who was sent down to Columbus on Sunday after the team activated right-hander Jason Bergmann.
Bergmann, 25, will start for the Nationals in Monday night's series opener against the Braves. Bergmann was placed on the DL on May 18 (retroactive to May 15) with right elbow inflammation.
The 29 year-old Jimenez is hitting .368 with 13 doubles, seven home runs, 25 RBIs and a .461 on-base percentage in 50 games with the Clippers. He went 1-for-14 (.071) in 17 games with Washington earlier this season.
Schroder, 28, has worked one scoreless inning with the Nationals in 2007.
Bill Ladson is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.