Guzman has had bouts of soreness in his foot because of bunions that will likely prevent him from taking the field throughout the rest of the current road trip, which ends after Wednesday's contest in San Diego.
Interim manager Jim Riggleman suggested that rest is best for Guzman's recuperation.
"He's just tender," Riggleman said. "He's got a situation there on his foot that he has tried to play through, and he keeps trying to play through, and it just keeps getting worse. We're going to let it calm down for a few days. He might be available to pinch-hit, I don't want to put him in a situation where he's playing defense and has to stand around on it for a while."
Alberto Gonzalez started at shortstop on Monday in San Diego. Mike Morse has played 57 games at the position over parts of four seasons in the Majors, but thus far has been strictly an outfielder for the Nationals.
Guzman has hit .302 with six home runs and 46 RBIs in 110 games this season.
Tim Powers is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.