But with Washington scheduled for an off-day Thursday, Williams decided to hold Werth out of Wednesday's lineup so he could rest the "barking" knee.
Bryce Harper shifted to right field and Scott Hairston started in left. Hairston hit second and Anthony Rendon, who went 3-for-5 Tuesday, moved into Werth's spot in the No. 3 hole.
"We hope having two days off will help it calm down for him," Williams said. "We'll give him some treatment and some anti-inflammatories. I think he's fine. It's one of those things where you go through the season and things creep up on you, so if we can, we need to give him a day."
Werth entered into Wednesday's 6-4 loss to the Rockies during the seventh as a pinch-hitter and struck out before adding an RBI single in a two-run ninth-inning rally that fell short.
Nick Kosmider is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.